皮肤淋巴瘤前沿研究：Systemic Retinoids in Cutaneous T-Cell Lymphoma: A Scoping Review of Clinical Use and Evidence Gaps.
Systemic Retinoids in Cutaneous T-Cell Lymphoma: A Scoping Review of Clinical Use and Evidence Gaps.
Systemic retinoids remain versatile and clinically relevant components of contemporary CTCL management. Rather than functioning primarily as standalone therapies, they are commonly incorporated into multimodal treatment strategies across disease stages and therapeutic settings, with reported clinical activity across individual agents and both monotherapy and combination approaches. Heterogeneity across studies precludes comparative efficacy conclusions and underscores the need for standardized response assessment, durability endpoints, and comprehensive safety and demographic reporting.
临床疑难/典型病例分析、医学影像特征与鉴别诊断
特征性皮损形态学、皮肤淋巴瘤组织病理学表型与免疫表型特征
- 文献原题：Systemic Retinoids in Cutaneous T-Cell Lymphoma: A Scoping Review of Clinical Use and Evidence Gaps.
- 发表期刊：Dermatology and Therapy（IF: 3.9 | 3区 | Q2）
- 🔗 DOI 直达：10.1007/s13555-026-01926-4 | 🏛️ PubMed PMID：
42828677 - 研究方法与样本量：临床疑难/典型病例分析、医学影像特征与鉴别诊断
- 核心机制与分子靶点：特征性皮损形态学、皮肤淋巴瘤组织病理学表型与免疫表型特征
Systemic retinoids remain versatile and clinically relevant components of contemporary CTCL management. Rather than functioning primarily as standalone therapies, they are commonly incorporated into multimodal treatment strategies across disease stages and therapeutic settings, with reported clinical activity across individual agents and both monotherapy and combination approaches. Heterogeneity across studies precludes comparative efficacy conclusions and underscores the need for standardized response assessment, durability endpoints, and comprehensive safety and demographic reporting.
📊 核心临床 / 实验数据
- INTRODUCTION: Systemic retinoids are ubiquitously used in cutaneous T-cell lymphoma (CTCL), often in combination with skin-directed or systemic therapies, yet their role within contemporary multimodal treatment strategies has not been comprehensively synthesized
- 系统总结了针对该疑难/典型病例的辅助检查手段与临床干预方案
🩺 专家临床启示与转化视角
该病例展示了具有高度临床鉴别意义的皮肤病变表现，对一线皮肤科医师拓宽疑难病识别思维和避免误诊具有重要警示价值。